Investigation, development and correlation of suitable ex-vivo and in-vivo models in the context of the biocompatibility of additivemanufactured permanent and resorbable materials in large animals

As part of FP-2, a large-animal study will be conducted to test permanent implant materials. In addition to evaluating the micromorphological effects of additively manufactured implant materials on the surrounding tissue, the in vivo study aims to assess the influence of different defect models and varying service lives. The most effective test specimens from FP-1 will be tested. Furthermore, the influence of tissue integration - both in general and at different stages - on the long-term stability of the implants and the implant-tissue interface will be characterized. A key focus of SP-5 is the establishment and testing of an intraoral ex vivo wound model, with the aim of simulating complex healing processes of the oral mucosa in a physiological environment. In this model, test specimens that do not meet the requirements for the subsequent use of resorbable test specimens are to be excluded in a cascade-like manner. These results are to be utilized and transferred to the second large-animal trial with resorbable biomaterials such as magnesium, in which an intraoral defect model is to be developed in a miniature pig, making the results transferable to the subsequent application of, for example, clinically relevant meshes. In the final year, the results of the ex vivo and in vivo experiments will be correlated and compared (WP 4, WP 6).